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Interview with Stephanie Planque from Covalent Bioscience

Reading time 8 min
Views 98

What is ageing? We can define ageing as a process of accumulation of the damage which is just a side-effect of normal metabolism. While researchers still poorly understand how metabolic processes cause damage accumulation, and how accumulated damage causes pathology, the damage itself – the structural difference between old tissue and young tissue – is categorized and understood pretty well. By repairing damage and restoring the previous undamaged – young – state of an organism, we can really rejuvenate it! It sounds very promising, and so it is. And for some types of damage (for example, for senescent cells) it is already proved to work!

Today in our virtual studio, somewhere between cold, rainy Saint-Petersburg and warm, sunny Huston, we meet Stephanie Planque! For those of you who are not familiar with her, here is a brief introduction.

Stephanie Planque was awarded the PhD in 2009 by the University of Texas-Houston Medical School for her advances in applying electrophilic analogs of proteins to decipher the beneficial and harmful functional effects of catabodies. She then expanded her focus to vaccination and therapeutic catabody identification using proprietary electrophilic target analogs. Her work was published in 49 peer-reviewed scientific articles, she has numerous national/international conference presentations. She moved fulltime as a co-founder to Covalent Bioscience in 2018 to focus on rapidly translating their electrophilic vaccine/catabody technologies to clinical reality.

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Total votes 5: ↑4 and ↓1 +3
Comments 0

SHA-256 Reversing in Bitcoin Systems as a Neural Machine Translation Problem

Level of difficulty Medium
Reading time 15 min
Views 301

Bitcoin is a digital currency created in January 2009 due to the housing market crash. It is designed to have lower transaction fees than traditional online payment mechanisms. Each Bitcoin transaction is recorded in a public log, but the identities of buyers and sellers remain anonymous. While this privacy feature allows users to conduct transactions without being traced, it also facilitates the buying and selling goods and services without leaving a trail. Bitcoin is built on cryptographic evidence, avoiding weaknesses inherent in trust-based models.  Cryptography is critical to the Bitcoin system as it maintains data secrecy and prevents unauthorized spending from another user's wallet. Advancements in cryptography have led to the development of various hashing algorithms to secure sensitive data. The SHA-256 hash function is widely recognized as a robust and extensively used cornerstone. However, the reversibility of hash functions remains a critical issue in cybersecurity. In the following essay, we propose that one-way cryptography processes based on hash functions can be reversed using neural networks in machine translation. Assuming this hypothesis is true and considering some quantity algorithms to decrypt certain types of hash functions, we will highlight their effects on the Bitcoin system.

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Total votes 8: ↑8 and ↓0 +8
Comments 0

After sale IT support for American and Western Companies

Reading time 2 min
Views 85

Title:

After sale IT support for American and Western Companies 

Let’s have a case study. 

A Russian IT company sells software to a western country like say America. And you are working as an application developer on the support side. 

One day, there is a problem with the program, and the program has stopped working. 

You must contact the company now to inform them that the program is off-line. 

THE NEXT STEP YOU TAKE IS VERY IMPORTANT. 

The way, the two cultures operate in a situation like this are very different and it will have everything to do with how easy your job goes for you.

…………

Russia : “we have a problem”

“What is wrong?”

“I don’t know”

“When can it be fixed?”

“I don’t know”

……………

USA: “i’m just giving you a real quick call to let you know that there is a problem with the program. 

I’ve already put my team on it and we will have it up and running shortly. 

I will let you know more by 3 o’clock today what is going on”

It’s not important how long you think it will take you, but I will always tell them a few hours from the time that you informed them of a problem.

I understand that you have no idea how deep the bug is and also whether it will affect any other systems.

But it is important to set a time window very close to when you inform them that you will bring them more information. 

This also works very well if you don’t know something that they ask you.

Question:

“What can we do to fix this problem?”

Answer: 

“I understand what you’re saying. I will look into it and get back to you in two hours.  By 1 PM today.”

in this case, it’s important that you: 

1. Take responsibility for yourself and your team.

   2. Communicate that you understand this responsibility.

   3. Gives strict timelines. (if it’s not possible, you can always say that there is a problem, but do it before the deadline.) 

    4. Use certain key language.

“ I understand you”

“ I understand what you were saying”

“ I wanted to inform you”

“ we are working on it right now”

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Total votes 2: ↑1 and ↓1 0
Comments 0

How to send messages over sockets and create your own messanging protocols in C++

Level of difficulty Medium
Reading time 28 min
Views 590

Network programming in C++ can be challenging. But even a greater challenge is to find educational content that will arm you with the knowledge on how to apply your networking skills in real applications.

In this article you can learn the basics of socket communication and many ways how you can design your internal messaging protocols.

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Total votes 2: ↑2 and ↓0 +2
Comments 2

How to Bypass reCaptcha in Selenium Automatically with Code Example

Level of difficulty Easy
Reading time 4 min
Views 202

I based my approach on an English manual that caught my eye just a couple of days ago, and I decided to test it (since it's written by a captcha recognition service that I use, why not - by the way, guys from 2captcha - I accept thanks in the form of green bills, if you're interested))))

I've made some tentative attempts at automation and encountered a frequently arising problem: reCaptcha recognition.

Of course, I understand that there are many guides, manuals, and articles written on this topic, but let's agree - it's interesting to describe one's own experience.

Thus, without getting too lengthy and boring about why Selenium is necessary, how important it is for automation, when it appeared and who invented it, let's get to the crux:

To solve the problem, we'll use a demo page kindly provided by reCaptcha itself - https://recaptcha-demo.appspot.com/recaptcha-v2-checkbox.php:

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Rating 0
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Клавиатуру Keychron Q1 HE оснастили магнитными аналоговыми переключателями на эффекте Холла. Она стоит $214.

Переключатели на эффекте Холла способны различать лёгкое и полное нажатие клавиши. Q1 HE можно настроить с учётом этой опции. Также в клавиатуре есть функция «быстрого запуска», которая может регистрировать повторное нажатие клавиши в ту же секунду. В итоге на одну кнопку можно назначить до четырёх команд.

Настройка аналоговых функций осуществляется через веб-приложение Keychron, которое также позволит переназначать задачи и клавиши. 

Q1 HE можно использовать как проводным, так и беспроводным способом через Bluetooth или с помощью прилагаемого USB-ключа 2,4 ГГц.

Клавиатура получила алюминиевый корпус, а колпачки клавиш изготовлены из прочного двойного ПБТ. Они используют собственный профиль OSA Keychron в ретро-стиле, а также оснащены ввинчивающимися стабилизаторами, установленными на печатной плате. Линейные магнитные переключатели Gateron 2.0 технически допускают горячую замену, но только на другие переключатели с эффектом Холла.

Tags:
+4
Comments 4

Tesla предупредила, что налоговые льготы на покупку Model 3 в США урежут вдвое — с $7500 до $3750 к 1 января 2024 года. Эти изменения коснутся заднеприводной модели 3 и модели 3 Long Range.

Model 3 стоит от $36 тысяч и считается самой дешёвой в линейке Tesla.

Вероятно, автопроизводитель не может удовлетворить требования к поставщикам в соответствии с Законом о сокращении инфляции (IRA). Это может повлиять на налоговые льготы для моделей Y и Model X в следующем году.

На прошлой неделе министерство финансов США предложило новые рекомендации по налоговым льготам в рамках IRA. Начиная со следующего года, льготные авто «не могут содержать никаких компонентов аккумуляторной батареи, которые производятся или собираются иностранным предприятием, вызывающим озабоченность регуляторов». К таким заводам относятся принадлежащие, контролируемые или находящиеся под юрисдикцией или руководством правительств Китая, России, Северной Кореи и Ирана.

Tags:
+3
Comments 0

Zoom незаметно выпустил версию приложения для Apple TV. Оно появилось в магазине tvOS.

Обновление Apple tvOS 17 включило функцию Continuity Camera для Apple TV, что позволило использовать iPhone или iPad в качестве веб-камеры для FaceTime на телевизоре. 

Использовать новое приложение Zoom довольно просто — нужно перейти по URL-адресу сопряжения, чтобы ввести код, отображаемый на телевизоре, или учётные данные. После входа в систему подключение осуществляется так же, как при использовании FaceTime на Apple TV. 

Sigmund Judge / X
Sigmund Judge / X

Если поделиться Apple TV с несколькими пользователями, то появится список учётных записей на ближайших устройствах, и после их выбора можно будет запустить сопряжение.

Приложение позволит начинать собрания или присоединяться к ним, приглашать людей и просматривать чаты. 

Tags:
0
Comments 0

Why x^0 = 1 visually

Reading time 3 min
Views 637

The traditional definition for the operation of exponentiation to a natural power (or a positive integer) had introduced approximately as follows:

Exponentiation is an arithmetic operation originally defined as the result of multiple multiplications a number by itself.

But the more precise formulation is still different:

Raising a number X to an integer power N is an arithmetic operation defined as the result of multiple [N by mod times] multiplications or divisions one by number X.

Let's figure it out under the cut! >>
Total votes 5: ↑5 and ↓0 +5
Comments 0

Американские сенаторы представили проект Закона о защите конфиденциальности путешественников, который запретит использование технологий распознавания лиц на транспортных узлах. Если его примут, то у сотрудников транспортной безопасности будет 90 дней на то, чтобы прекратить использование технологии и удалить все биометрические данные.

Биометрию ранее начали тестировать в 30 аэропортах США, а планировали расширить проект до 430 авиаузлов.

Система Credential Authentication Technology 2 (CAT-2) разработана французской Idemia. «Биометрический хаб» Интерпола объединяет существующие базы данных преступников с другими технологиями Idemia. Система путём сканирования лиц и документов выявляет поддельные удостоверения личности.

Противники системы раскритиковали её за расовую предвзятость.

Профессор информатики Университета Иллинойса Шелдон Джейкобсон же отметил, что «распознавание лиц не имеет ничего общего с вмешательством правительства в личную жизнь людей».

Tags:
+2
Comments 0

Утечки изображений будущего Samsung Galaxy S24 показывают, что смартфон выйдет в титановом корпусе. При этом Galaxy S24 Ultra получит новый дизайн плоского экрана. 

Samsung, как ожидается, выпустит новое программное обеспечение с функциями ИИ, использующее собственную модель Gauss компании. S24 будут использовать эту технологию для перевода сообщений в мессенджерах в режиме реального времени и на более чем десять языков. В октябре Samsung также продемонстрировала новую функцию кадрирования камеры Zoom Anyplace на базе искусственного интеллекта, которая, как ожидается, будет работать в смартфонах.

FCC недавно опубликовала основные характеристики процессоров и модемов для линейки S24. Модели S24, S24 Plus и S24 Ultra оснащены модемами Qualcomm с функцией Smart Transit, что подтверждает использование чипа Snapdragon 8 Gen 3 с поддержкой ИИ.

S24 Ultra также получит 50-мегапиксельный телеобъектив с 5-кратным увеличением и поддержку Wi-Fi 7. Похоже, что он по-прежнему будет иметь 6,8-дюймовый экран Quad-HD, частоту обновления 120 Гц, 12 ГБ оперативной памяти и аккумулятор ёмкостью 5000 мАч.

Наконец, смартфоны получат новые цветовые решения: чёрный оникс, мраморно-серый, кобальтово-фиолетовый и янтарно-жёлтый. 

Tags:
0
Comments 0

Crafting Enhanced Dropdown Interactions with Svelte: Constructing an Advanced Dropdown Component with Svelte

Level of difficulty Medium
Reading time 3 min
Views 174

In the realm of frontend development, the quest for enhancing user interaction remains a constant pursuit. Developers, inspired by innovation, often seek solutions to refine components for a seamless user experience. Today, we delve into the construction of an advanced dropdown component using Svelte — a framework known for its simplicity and effectiveness.

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Total votes 3: ↑3 and ↓0 +3
Comments 0

Илон Маск «послал к чёрту» рекламодателей. В ходе интервью на конференции DealBook он сначала признавал свои ошибки, в том числе связанные с антисемитскими комментариями, а затем атаковал рекламодателей.

При ответе на вопрос об уходе компаний с платформы Х Маск заявил: «Не размещайте рекламу. Если кто-то попытается шантажировать меня рекламой, шантажировать меня деньгами, идите к чёрту. Это ясно? Я надеюсь, что ясно». Он особо выделил генерального директора Disney Боба Айгера, который ранее в тот же день заявил, что не хочет ассоциировать свою компанию с Маском. 

Если рекламодатели не вернутся, «рекламный бойкот приведёт к гибели компании», признал глава Х.

Tags:
+6
Comments 0

A short guide to UX writing and its role in UX design

Level of difficulty Medium
Reading time 5 min
Views 316

UX writing is an essential part of UX design, which plays a huge role in providing qualitative user experience. The job of a UX writer is to compose texts for a digital product, which can be of two types: microcopy (labels, buttons, notifications and other small notes) and macrocopy (larger texts like written content on pages, instructions, information sheets). UX writing helps users easily navigate through the product, perform various tasks and get all the necessary information.

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Rating 0
Comments 1

Autoload the Intel RST VMD driver for Windows 10/11 installation with Ventoy

The VMD Controller is enabled by default on many motherboards and laptops with Intel 11th Gen and newer mobile CPUs. And it is necessary to load the controller driver from a USB drive when installing Windows from the original installation media. But Ventoy with the Injection plugin can do this automatically without any user interaction.

Download SetupRST.exe from intel.com. Current version: 19.5.2.1049.
Run SetupRST.exe -extractdrivers RST extract the driver files to
RST\production\Windows10-x64\15063\Drivers\VMD folder.

Write VentoyAutoRun.bat file that contains:

if "%PROCESSOR_ARCHITECTURE%"=="AMD64" drvload "X:\VMD\iaStorVD.inf"

Create an archive IRST-VMD-19.7z containing the VMD folder and the VentoyAutoRun.bat file, and then copy it to the Ventoy USB drive.

Next, we need to create or edit the ventoy.json config file in the ventoy folder in the root of the Ventoy USB drive.

{
    "injection": [
        {
            "parent": "/win1011",
            "archive": "/IRST-VMD-19.7z"
        }
    ]
}

We instruct Ventoy to apply the archive IRST-VMD-19.7z when booting Windows 10/11.ISO from a folder win1011 in the root of the Ventoy USB drive.

Download the pre-created driver archive and config files IRST-VMD-19-ventoy.

Tags:
0
Comments 0

Your Name: Why it’s Important in American Sales and Marketing

Reading time 2 min
Views 561

This is one of the most important articles I’ve written. 

In this article, I’m going to dive deep into one of the largest differences between Russia and America pertaining to sales and marketing. 

1. You must use your name. 

2. You must have a personal approach. 

3. You must show that you are involved. 

4. You must show that you care about the needs and desires of the client. 

Recently, I was faced with an interesting problem. I was asked to call clients without making it personal. 

So let’s go back to when I was in America, living and working as a sales person. The company I work for, was very large, and had multiple branches around the Washington DC area. They had offices in three states. 

They put me through a sales training course. 

The biggest “take away” from the course….. 

You’re not selling the product/ 

you’re selling yourself. 

It's important to use your charisma and your genuine caring for the customer to win them over. Once they understand that you're actually trying to help them, then they will seriously consider the item you are telling them about. 

I also want to say, very clearly, that it's not a prideful approach. It should be a professional approach. You're responsible to tell the customer/ the client all the benefits of the item and how this item will help their business.

Everything above pertains to sales in America. So if you are approaching America as a sales manager this is how you should craft your approach. 

Now I've spoken to my colleague,

Kristina Pashnina and we have agreed upon some stark differences to the Russian sales climate. Here she will begin to tell you how the Russians see sales. 

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Total votes 1: ↑1 and ↓0 +1
Comments 4

Empowering Digital Artists: Building a Royalty-Enabled NFT Marketplace

Level of difficulty Easy
Reading time 5 min
Views 296

As NFTs spread across the world, users spent millions of dollars to buy digital assets to prove their uniqueness. Many creators and artists showcase their beautiful products, such as artworks, music, etc., in the NFT marketplace. What if a creator can profit from their work even after selling it to another business? This is where royalty comes in; it is a recent addition to the NFT space. Owing NFT royalties can benefit artists and creators from succeeding sales to the business. 

Once NFT royalties became a hot topic and gained popularity among artists and creators. Later, arguments were evolved to remove royalties that had swayed other NFT creators. DeGods, the popular Solana's NFT project, has moved its royalty model to 0%. However, creating a royalty-based NFT marketplace attracts many creators around the world. In this article, we will delve into the development process of NFT marketplace royalties and how it benefits enthusiastic artists from secondary sales. 

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Total votes 3: ↑3 and ↓0 +3
Comments 1

Exploring VALID/READY protocol, pipelines and experimenting with flow control using an HDL training tool

Level of difficulty Medium
Reading time 1 min
Views 473

Ссылка на русскую версию / link to Russian version

Understanding valid/ready protocol is extremely important for every microarchitect.

Valid/ready is one of the main protocols used to organise flow-control inside a logic block as well as on inter-block (SoC) level.

In the last lesson, we explored FIFO buffer using hdlgadgets - human-in-the-loop HDL training tool.

This time we will take two FIFO buffers (which form a pipeline with valid/ready handshakes) and will experiment with it by changing flow-control logic of the pipeline.

We will show that valid/ready is not only a mechanism for transferring data from one FIFO queue to another, but also a method for organizing various kinds of logical functionality between queues.

If you have not worked with valid/ready protocol before, you will be surprised how easy it is to achieve desired functionality of the design by simply writing couple of lines of Verilog code in the handshaking logic block between two FIFOs.

Read further and watch the video
Total votes 6: ↑6 and ↓0 +6
Comments 0