Maryland Bionetworking Summit - February 8th - Register Today!
Please join us on Wednesday, February 8th from 6-8pm for a bioscience-focused networking event series designed to highlight the area’s unique life science ecosystem and to promote interactions between its diverse stakeholders. Sponsored and organized by the University of Maryland, Baltimore County, the Institute for Bioscience and Biotechnology Research (IBBR)...
The Andrianov Lab Receives Sub-Award to Aid in the Development of a Dissolvable Microneedle Patch Vaccine against the Dangerous Nipah virus and Hendra virus
The University of Maryland - Institute for Bioscience and Biotechnology Research (IBBR) Fellow, Dr. Alexander Andrianov received a two-year $290,000 sub award from the Henry M. Jackson Foundation for the Advancement of Military Medicine on behalf of Uniformed Services University (USU) in Bethesda, MD, as part of a multi-million dollar...
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IBBR Co-Director David Weber Selected as MPower Professor
Dr. David Weber, Co-Director of the Institute for Bioscience and Biotechnology Research (IBBR), Director of the Center for Biomolecular Therapeutics (CBT), Director of the Maryland Center for Advanced Molecular Analysis (M-CAMA), and a Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine,...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
IBBR/NIST Seminar: Livia Schiavinato Eberlin
Baylor College of Medicine
Monday, February 13, 2023 - 11:00am
Andrew Webb
Leiden University Medical Center
Tuesday, February 21, 2023 - 11:00am
Recent Publications
Electrogenetic signaling and information propagation for controlling microbial consortia via programmed lysis.
To probe signal propagation and genetic actuation in microbial consortia, we have coopted the components of both redox and quorum sensing (QS) signaling into a communication network for guiding...
hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties.
Human ether-a-go-go-related gene (hERG) potassium channel is well-known contributor to drug-induced cardiotoxicity and therefore an extremely important target when performing safety assessments of...
DOTAP: STRUCTURE, HYDRATION, AND THE COUNTERION EFFECT.
The cationic lipid 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP) is one of the original synthetic cationic lipids used for the liposomal transfection of oligonucleotides in gene therapy. The...
Design and characterization of a protein fold switching network.
To better understand how amino acid sequence encodes protein structure, we engineered mutational pathways that connect three common folds (3α, β-grasp, and α/β-plait). The structures of...
Murine Toxicology and Pharmacokinetics of Lead Next Generation Galeterone Analog, VNPP433-3β.
VNPP433-3β (compound 2, (3β-(1H-imidazole-1-yl)-17-(1H-benzimidazole-1-yl)-androsta-5,16-diene), a multitarget anticancer agent has emerged as our lead next generation galeterone analogs (NGGA)....