Triggering interventions for influenza: the ALERT algorithm
- PMID: 25414260
- PMCID: PMC4304363
- DOI: 10.1093/cid/ciu749
Triggering interventions for influenza: the ALERT algorithm
Abstract
Background: Early, accurate predictions of the onset of influenza season enable targeted implementation of control efforts. Our objective was to develop a tool to assist public health practitioners, researchers, and clinicians in defining the community-level onset of seasonal influenza epidemics.
Methods: Using recent surveillance data on virologically confirmed infections of influenza, we developed the Above Local Elevated Respiratory Illness Threshold (ALERT) algorithm, a method to identify the period of highest seasonal influenza activity. We used data from 2 large hospitals that serve Baltimore, Maryland and Denver, Colorado, and the surrounding geographic areas. The data used by ALERT are routinely collected surveillance data: weekly case counts of laboratory-confirmed influenza A virus. The main outcome is the percentage of prospective seasonal influenza cases identified by the ALERT algorithm.
Results: When ALERT thresholds designed to capture 90% of all cases were applied prospectively to the 2011-2012 and 2012-2013 influenza seasons in both hospitals, 71%-91% of all reported cases fell within the ALERT period.
Conclusions: The ALERT algorithm provides a simple, robust, and accurate metric for determining the onset of elevated influenza activity at the community level. This new algorithm provides valuable information that can impact infection prevention recommendations, public health practice, and healthcare delivery.
Keywords: hospital epidemiology; infection control; influenza; outbreak detection; surveillance.
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Figures
Similar articles
-
Evaluating the ALERT algorithm for local outbreak onset detection in seasonal infectious disease surveillance data.Stat Med. 2020 Apr 15;39(8):1145-1155. doi: 10.1002/sim.8467. Epub 2020 Jan 27. Stat Med. 2020. PMID: 31985869 Free PMC article.
-
National Influenza Surveillance in the Philippines from 2006 to 2012: seasonality and circulating strains.BMC Infect Dis. 2016 Dec 19;16(1):762. doi: 10.1186/s12879-016-2087-9. BMC Infect Dis. 2016. PMID: 27993136 Free PMC article.
-
Improving regional influenza surveillance through a combination of automated outbreak detection methods: the 2015/16 season in France.Euro Surveill. 2017 Aug 10;22(32):30593. doi: 10.2807/1560-7917.ES.2017.22.32.30593. Euro Surveill. 2017. PMID: 28816649 Free PMC article.
-
Seasonal and pandemic influenza surveillance considerations for constructing multicomponent systems.Influenza Other Respir Viruses. 2009 Mar;3(2):51-8. doi: 10.1111/j.1750-2659.2009.00077.x. Influenza Other Respir Viruses. 2009. PMID: 19496841 Free PMC article. Review.
-
[Epidemiological surveillance of influenza. Principles, means, possibilities].Bacteriol Virusol Parazitol Epidemiol. 2007 Jul-Dec;52(3-4):163-80. Bacteriol Virusol Parazitol Epidemiol. 2007. PMID: 19326730 Review. Romanian. No abstract available.
Cited by
-
Front-Line Emergency Department Clinician Acceptability and Use of a Prototype Real-Time Cloud-Based Influenza Surveillance System.Front Public Health. 2021 Nov 4;9:740258. doi: 10.3389/fpubh.2021.740258. eCollection 2021. Front Public Health. 2021. PMID: 34805066 Free PMC article.
-
Evaluating the ALERT algorithm for local outbreak onset detection in seasonal infectious disease surveillance data.Stat Med. 2020 Apr 15;39(8):1145-1155. doi: 10.1002/sim.8467. Epub 2020 Jan 27. Stat Med. 2020. PMID: 31985869 Free PMC article.
-
N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial.JAMA. 2019 Sep 3;322(9):824-833. doi: 10.1001/jama.2019.11645. JAMA. 2019. PMID: 31479137 Free PMC article. Clinical Trial.
-
Algorithms for detecting and predicting influenza outbreaks: metanarrative review of prospective evaluations.BMJ Open. 2016 May 6;6(5):e010683. doi: 10.1136/bmjopen-2015-010683. BMJ Open. 2016. PMID: 27154479 Free PMC article.
-
Tracking Cholera through Surveillance of Oral Rehydration Solution Sales at Pharmacies: Insights from Urban Bangladesh.PLoS Negl Trop Dis. 2015 Dec 7;9(12):e0004230. doi: 10.1371/journal.pntd.0004230. eCollection 2015 Dec. PLoS Negl Trop Dis. 2015. PMID: 26641649 Free PMC article.
References
-
- Hoyert DL, Xu JQ. Deaths: preliminary data for 2011. Hyattsville, MD: National Vital Statistics Reports, National Center for Health Statistics; 2012.
-
- US Census Bureau. Table 1103: Motor vehicle accidents—number and deaths: 1990 to 2009. 2012. p. 693. Available at: http://www.census.gov/compendia/statab/2012/tables/12s1103.pdf . Accessed 13 August 2013.
-
- Dushoff J. Mortality due to influenza in the United States—an annualized regression approach using multiple-cause mortality data. Am J Epidemiol. 2005;163:181–7. - PubMed
-
- Thompson WW, Shay DK, Weintraub E, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA. 2003;289:179–86. - PubMed
-
- Thompson MG, Shay DK, Zhou H, et al. Estimates of deaths associated with seasonal influenza—United States, 1976–2007. MMWR Morb Mortal Wkly Rep. 2010;59:1057–62. - PubMed
Publication types
MeSH terms
Grant support
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical