(pyruvate dehydrogenase (acetyl-transferring))-phosphatase
[pyruvate dehydrogenase (lipoamide)] phosphatase | |||||||||
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Identifiers | |||||||||
EC no. | 3.1.3.43 | ||||||||
CAS no. | 9073-70-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) is an enzyme that catalyzes the chemical reaction
- [pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
Thus, the two substrates of this enzyme are pyruvate dehydrogenase (acetyl-transferring) phosphate and H2O, whereas its two products are pyruvate dehydrogenase (acetyl-transferring) and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.
Structural studies[edit]
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.
References[edit]
- Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ (1972). "-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart". Arch. Biochem. Biophys. 148 (2): 327–42. doi:10.1016/0003-9861(72)90151-8. PMID 4401694.
- Reed LJ, Damuni Z, Merryfield ML (1985). "Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Curr. Top. Cell. Regul. Current Topics in Cellular Regulation. 27: 41–9. doi:10.1016/b978-0-12-152827-0.50011-6. ISBN 9780121528270. PMID 3004826.