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    medicine категориясындагы мыкты электрондук китептер

    An accessible guide to more than 90 of the most important and groundbreaking milestones in the history of medicine, and the people behind them.

    How are illnesses diagnosed? What is cancer? Why are some pandemics so deadly?

    This ebook explores big questions like these, explaining the breakthroughs and discoveries that have shaped our modern-day understanding of medicine and helped us protect and promote our health. Written in plain English, The Medicine Book cuts through the jargon and is packed with pithy explanations of the most important milestones in medical history, with step-by-step diagrams and witty illustrations that untangle knotty concepts.

    From ancient medical practices, such as herbal medications and balancing the humours, through groundbreaking work including Jenner's experiments with cowpox, which laid the basis for vaccination, The Medicine Book offers an engaging overview of medical history across the world all the way into the 21st century with gene manipulation, immunotherapy, and robotics and telesurgery. Covering the role that therapies and drugs have played in the human quest to treat and prevent disease, the establishment of hospitals and later international medical bodies, like the WHO, and medical science's response to new challenges, such as accelerated antibiotic resistance and COVID-19, The Medicine Book explains the stories behind each milestone development.

    Continuing the "Big Ideas" series' trademark combination of authoritative, informative text, and bold graphics, The Medicine Book uses an innovative visual approach to make the subject accessible to everyone, whether you're a student of medicine or science, a medical professional, or an armchair expert.
    Speech and Voice Science Workbook, Fourth Edition is an excellent companion to the textbook Speech and Voice Science, Fourth Edition. Divided into chapters that correspond with Speech and Voice Science, this workbook is designed to provide a valuable tool for students to expand their understanding of this challenging course subject. The workbook is intended to be used for student review, self-study and exam preparation, to highlight areas of confusion, to learn new concepts, to connect ideas, and to spark new questions and thoughtful discussions.

    There are four different types of sections that appear throughout the workbook: Foundational Knowledge questions, Conceptual Integration questions, and Clinical Application questions, and TRY IT! Activities. Each section is tailored to hone different skill sets and enhance comprehension of the topics as follows:


    Foundational Knowledge questions assess students’ basic knowledge gained from the textbook and highlight areas they need to review

    Conceptual Integration questions prompt students to delve deeper into the material and interrelate diverse information for understanding

    Clinical Application questions explore the usefulness of the material provided in the textbook to answer the common student query “How does speech and voice science relate to the field of communication sciences and disorders?”

    TRY IT! activities are designed to promote experiential learning and allow students to explore concepts and acquire new insights

    Key Features:

    * Over 1,000 questions are included on a wide variety of topics

    * Informative answers are provided to over 45 questions on the 14 Clinical Cases presented in the textbook

    * Numerous original figures and spectrograms are used to illustrate questions, reinforce key concepts, and assess students’ understanding

    * A variety of question formats, including multiple choice, true/false, fill-in, matching, figure identification, drawing, and short answer

    * A focus on integrating knowledge for deeper understanding


    From medical expert Leana Wen, MD, Lifelines is an insider's account of public health and its crucial role—from opioid addiction to global pandemic—and an inspiring story of her journey from struggling immigrant to being one of Time’s 100 Most Influential People.

    “Public health saved your life today—you just don’t know it,” is a phrase that Dr. Leana Wen likes to use. You don’t know it because good public health is invisible. It becomes visible only in its absence, when it is underfunded and ignored, a bitter truth laid bare as never before by the devastation of COVID-19.

    Leana Wen—emergency physician, former Baltimore health commissioner, CNN medical analyst, and Washington Post contributing columnist—has lived on the front lines of public health, leading the fight against the opioid epidemic, outbreaks of infectious disease, maternal and infant mortality, and COVID-19 disinformation. Here, in gripping detail, Wen lays bare the lifesaving work of public health and its innovative approach to social ills, treating gun violence as a contagious disease, for example, and racism as a threat to health.

    Wen also tells her own uniquely American story: an immigrant from China, she and her family received food stamps and were at times homeless despite her parents working multiple jobs. That child went on to attend college at thirteen, become a Rhodes scholar, and turn to public health as the way to make a difference in the country that had offered her such possibilities.

    Ultimately, she insists, it is public health that ensures citizens are not robbed of decades of life, and that where children live does not determine whether they live.
    A masterpiece of science reporting that tracks the animal origins of emerging human diseases, Spillover is “fascinating and terrifying … a real-life thriller with an outcome that affects us all” (Elizabeth Kolbert, author of The Sixth Extinction). In 2020, the novel coronavirus gripped the world in a global pandemic and led to the death of hundreds of thousands. The source of the previously unknown virus? Bats. This phenomenon—in which a new pathogen comes to humans from wildlife—is known as spillover, and it may not be long before it happens again.

    Prior to the emergence of our latest health crisis, renowned science writer David Quammen was traveling the globe to better understand spillover’s devastating potential. For five years he followed scientists to a rooftop in Bangladesh, a forest in the Congo, a Chinese rat farm, and a suburban woodland in New York, and through high-biosecurity laboratories. He interviewed survivors and gathered stories of the dead. He found surprises in the latest research, alarm among public health officials, and deep concern in the eyes of researchers.

    Spillover delivers the science, the history, the mystery, and the human anguish of disease outbreaks as gripping drama. And it asks questions more urgent now than ever before: From what innocent creature, in what remote landscape, will the Next Big One emerge? Are pandemics independent misfortunes, or linked? Are they merely happening to us, or are we somehow causing them? What can be done? Quammen traces the origins of Ebola, Marburg, SARS, avian influenza, Lyme disease, and other bizarre cases of spillover, including the grim, unexpected story of how AIDS began from a single Cameroonian chimpanzee. The result is more than a clarion work of reportage. It’s also the elegantly told tale of a quest, through time and landscape, for a new understanding of how our world works—and how we can survive within it.
    The #1 New York Times bestselling account of a neurosurgeon's own near-death experience—for readers of 7 Lessons from Heaven.

    Thousands of people have had near-death experiences, but scientists have argued that they are impossible. Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.

    Then, Dr. Alexander’s own brain was attacked by a rare illness. The part of the brain that controls thought and emotion—and in essence makes us human—shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexander’s eyes popped open. He had come back.

    Alexander’s recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine source of the universe itself.

    Alexander’s story is not a fantasy. Before he underwent his journey, he could not reconcile his knowledge of neuroscience with any belief in heaven, God, or the soul. Today Alexander is a doctor who believes that true health can be achieved only when we realize that God and the soul are real and that death is not the end of personal existence but only a transition.

    This story would be remarkable no matter who it happened to. That it happened to Dr. Alexander makes it revolutionary. No scientist or person of faith will be able to ignore it. Reading it will change your life.
    Ensure that you’re thoroughly prepared for the Family Nurse Practitioner (FNP) certification exam with more than 1,500 questions! Family Nurse Practitioner Certification Review, 3rd Edition reflects the latest evidence-based clinical practice and national treatment guidelines and protocols. This comprehensive resource features more than 1,500 high-quality multiple-choice questions with detailed rationales for correct answers. Questions related to patient safety are highlighted with a QSEN safety icon to highlight the graduate-level safety competency of the Quality & Safety Education for Nurses initiative. It also includes a companion Evolve website with virtually unlimited, randomly generated practice exams that match the length and question distribution of the actual AANP and ANCC FNP certification exams.
    • More than 1,500 multiple-choice questions with by detailed rationales
    • help students understand the reasoning behind each answer.
    • Division of clinical chapters into Physical Examination and Diagnostic Tests, Disorders, and Pharmacology makes it easy for students to locate specific information within each system.
    • Chapters on Research and Theory and Professional Issues provide information on professional competencies important to the FNP role.
    • Multiple-choice questions that mirror FNP certification exam formats give you realistic exam practice.
    • NEW! Updated questions
    • throughout review the latest evidence-based clinical practice and national treatment guidelines and protocols to prepare students for the AANP and ANCC FNP certification exams and clinical practice.
    • NEW! Questions emphasizing patient safety are highlighted to reinforce the graduate-level safety competency of the Quality & Safety Education for Nurses initiative.
    Print version of the book includes free access to the app (web, iOS, and Android), which offers interactive Q&A review plus the entire text of the print book! Please note the app is included with print purchase only.

    The only book designed specifically to prepare students for the Adult-Gerontology Acute Care Nurse Practitioner (AG-ACNP) exams, this unparalleled review details the step-by-step journey from classroom to patient room and beyond. This book begins with proven test-taking strategies for students and provides an overview of common pitfalls for exam takers. It features question styles and content material from both the American Association of Critical-Care Nurses (AACN®) and American Nurses Credentialing Center (ANCC) exams, providing an overview of the certification exams written specifically by the certification organizations themselves.

    With more than 630 unique questions, this review contains completely up-to-date and evidence-based exam preparation. Practice questions are organized into body system review, special populations, and legal/ethical issues, and culminate in a 175-question practice test that represents the length, variety, and complexity of board exam questions. All questions’ answers have accompanying rationales based on clinical practice guidelines. Completely unique to this publication, the last section of Adult-Gerontology Acute Care Nurse Practitioner Q&A Review guides one through the next steps after the exam—how to progress into practice with your new certification.

    KEY FEATURES

    • Over 630 practice questions with answers and rationales
    • The only current book publication designed specifically to prepare students for the AG-ACNP exams
    • Contains the most current information and practice using published guidelines
    • Exam tips and perils/pitfalls to avoid in test-taking
    • Includes free access to interactive ebook and Q&A app—track and sync your progress on up to three devices!
    The new edition of this hugely successful book continues to present a unique understanding of the role of fascia in healthy movement and postural distortion which is of vital importance to bodyworkers and movement therapists worldwide. Fully updated throughout and now with accompanying website (www.myersmyofascialmeridians.com), Anatomy Trains: Myofascial Meridians for Manual and Movement Therapists will be ideal for all those professionals who have an interest in human movement: massage therapists, structural integration practitioners, craniosacral therapists, yoga teachers, osteopaths, manual therapists, physiotherapists, athletic trainers, personal trainers, dance and movement teachers, chiropractors and acupuncturists.
    • Provides a revolutionary approach to the study of human anatomy which has been shown to improve the outcomes of physical therapies traditionally used to manage pain and other musculoskeletal disorders
    • Describes a theory which is applicable to all common types of movement, posture analysis and physical treatment modalities
    • Layout designed to allow the reader to gather the concept quickly or gain a more detailed understanding of any given area according to need
    • Design icons direct readers to their own specialist areas of interest, e.g. manual therapy, movement therapy, visual assessment, kinaesthetic education or supplementary video material
    • Appendices discuss the relevance of the Anatomy Trains concept to the work of Dr Louis Schultz (Meridians of Latitude), Ada Rolf (Structural Integration) and the practice of Oriental Medicine
    • Accompanying website (www.myersmyofascialmeridians.com) presents multi-media exploration of the concepts described in the book - film clips from Kinesis DVDs, computer graphic representations of the Anatomy Trains, supplementary dissection photographs and video clips, webinars, and some extra client photos for visual assessment practice
    • Text updated in relation to the most up-to-date research originally published at the International Fascia Research Congress, Vancouver, 2012
    • Includes the latest evidence for the scientific basis of common clinical findings, including preliminary evidence from human fascial dissections
    • Explores the role of fascia as our largest sensory organ
    • Contains updates arising out of continual teaching and practice – for example, the role of the fascia and its interconnectivity in the generation of pain and/or force transmission
    • New chapter discusses the role of Anatomy Trains theory in the analysis of gait
    • Video clips on an associated website (www.myersmyofascialmeridians.com) present examples of the concepts explored in the book
    • Podcasts on the website explore the therapeutic techniques involved
    • Website addresses and references fully updated throughout
    New chapter on Destructive Leadership!

    The Fifth Edition of Peter G. Northouse’s best-selling Introduction to Leadership: Concepts and Practice provides readers with a clear, concise overview of the complexities of practicing leadership and concrete strategies for becoming better leaders. The text is organized around key leader responsibilities such as creating a vision, establishing a constructive climate, listening to outgroup members, and overcoming obstacles. Case studies, self-assessment questionnaires, observational exercises, and reflection and action worksheets engage readers to apply leadership concepts to their own lives. Grounded in leadership theory and the latest research, the fully updated, highly practical Fifth Edition includes a new chapter on destructive leadership, 18 new cases, and 5 new Leadership Snapshots. This title is accompanied by a complete teaching and learning package. Contact your SAGE representative to request a demo.
    • Digital Option / Courseware
      SAGE Vantage is an intuitive digital platform that delivers this text’s content and course materials in a learning experience that offers auto-graded assignments and interactive multimedia tools, all carefully designed to ignite student engagement and drive critical thinking. Built with you and your students in mind, it offers simple course set-up and enables students to better prepare for class. Learn more.
      • Assignable Video with Assessment
        Assignable video (available with SAGE Vantage) is tied to learning objectives and curated exclusively for this text to bring concepts to life. Watch a sample video now.
    • LMS Cartridge (formerly known as SAGE Coursepacks): Import this title’s instructor resources into your school’s learning management system (LMS) and save time. Don’t use an LMS? You can still access all of the same online resources for this title via the password-protected Instructor Resource Site. Learn more.

    Share with your students: 3 Key Components that Enable Destructive Leadership

    Prepare for success on certification exams and in perioperative nursing! Alexander’s Care of the Patient in Surgery, 16th Edition is the definitive text for nurses and surgical technologists training for a career in the operating room. Illustrated, step-by-step instructions cover patient care in more than 400 surgical interventions, including positioning, instrumentation, and postoperative care. New to this edition is additional coverage of robotic surgery, along with review of evidence-based guidelines for practice. From well-known educator Jane C. Rothrock — and with every chapter authored by an expert nurse — Alexander’s gives you the tools you need to provide safe, high-quality care in the surgical setting.
    • Over 400 general and specialty surgical interventions
    • are covered, as well as many minimally invasive surgical procedures, whether performed in a hospital, outpatient clinic, or in a doctor's office.
    • 900 full-color photos and illustrations show surgical anatomy, procedures, and methods.
    • Comprehensive coverage includes basic perioperative nursing principles, such as patient and environmental safety, infection prevention and control, positioning, anesthesia and pain management, the unique needs of special populations such as pediatric and geriatric patients, and more.
    • Comprehensive practice exams on the Evolve companion website include 300 exam-style questions with rationales.
    • Perioperative nursing considerations include assessment, nursing diagnosis, outcome identification, planning, implementation, evaluation, discharge planning, and patient and family education.
    • Sample plans of care include nursing diagnoses, outcomes, and interventions.
    • Surgical Pharmacology tables summarize the drugs most commonly used for each surgical procedure, including generic and trade names, indications, and pharmacokinetics.
    • Patient and Family Education boxes include specific guidelines for preprocedural and postprocedural care, side effects and complications, home care, discharge instructions, and psychosocial care.
    • Patient Safety boxes highlight Joint Commission initiatives for patient and staff safety in the surgical setting.
    • Best Practice and Research Highlight boxes apply the latest scientific research to patient care.
    • Critical thinking questions at the end of each chapter let you assess your understanding of important material.
    • NEW! Robotic-Assisted Surgery boxes highlight a rapidly expanding surgical modality.
    • NEW! Enhanced Recovery After Surgery boxes promote review of protocols for early recovery for patients undergoing major surgery.
    • NEW! Patient Engagement Exemplar boxes optimize surgical outcomes by addressing AORN guidelines on the issues of patient care and involvement of the patient’s family.
    • NEW standards and AORN toolkits cover topics ranging from enhanced post-surgical recovery to prevention of pressure ulcers.
    The authoritative presentation of Eye Movement Desensitization and Reprocessing (EMDR) therapy, this groundbreaking book--now revised and expanded--has been translated into 10 languages. Originally developed for treatment of posttraumatic stress disorder (PTSD), this evidence-based approach is now also used to treat adults and children with complex trauma, anxiety disorders, depression, addictive behavior problems, and other clinical problems. EMDR originator Francine Shapiro reviews the therapy's theoretical and empirical underpinnings, details the eight phases of treatment, and provides training materials and resources. Vivid vignettes, transcripts, and reproducible forms are included. Purchasers get access to a Web page where they can download and print the reproducible materials in a convenient 8 1/2" x 11" size.

    New to This Edition
    *Over 15 years of important advances in therapy and research, including findings from clinical and neurophysiological studies.
    *New and revised protocols and procedures.
    *Discusses additional applications, including the treatment of complex trauma, addictions, pain, depression, and moral injury, as well as post-disaster response.
    *Appendices with session transcripts, clinical aids, and tools for assessing treatment fidelity and outcomes.

    EMDR therapy is recognized as a best practice for the treatment of PTSD by the U.S. Departments of Veterans Affairs and Defense, the International Society for Traumatic Stress Studies, the World Health Organization, the U.K. National Institute for Health and Care Excellence (NICE), the Australian National Health and Medical Research Council, the Association of the Scientific Medical Societies in Germany, and other health care associations/institutes around the world.
    The quintessential guide to nursing diagnoses from NANDA-I experts in new updated edition

    Fully updated and revised by editors T. Heather Herdman, Shigemi Kamitsuru, and Camila Takáo Lopes, NANDA International Nursing Diagnoses: Definitions and Classification, 2021-2023, 12th Edition is the definitive guide to nursing diagnoses, as reviewed and approved by the NANDA International (NANDA-I) Diagnosis Development Committee (DDC). In this new edition of a seminal text, the editors have revised all introductory chapters, providing critical information needed for nurses to understand assessment, its link to diagnosis and clinical reasoning, and the purpose and use of taxonomic structure for nurses at the bedside. Researchers will also find new recommendations to improve the terminology.

    Additional Key Updates

    • 46 new nursing diagnoses and 67 revised diagnoses
    • Changes to 17 nursing diagnosis labels, ensuring they are consistent with current literature and reflect a human response
    • Refinement of the vast majority of the nursing diagnosis related/risk factors
    • Standardization of diagnostic indicator terms (defining characteristics, related factors, risk factors) to further aid clarity for students and clinicians
    • Coding of all terms for those using electronic versions of the terminology
    • Web-based resources include reference lists for new and revised diagnoses
    • New chapter on revised Level of Evidence Criteria for diagnosis submission

    Rigorously updated and revised, the new edition of this acclaimed text is a must-have resource for all nursing students, professional nurses, nurse educators, nurse informaticists, nurse researchers, and nurse administrators.

    Bringing together the clinical know-how of Kathy Bonewit-West, the administrative expertise of Sue Hunt, and the anatomy and physiology knowledge of Edith Applegate, this unique, hands-on text guides you through the medical knowledge and skills you need to succeed in today's fast-paced medical office. The latest standards and competencies for the medical assistant have been incorporated into this new edition, along with expanded coverage on important topics such as nutrition, the electronic medical record, ICD-10, emergency preparedness and disaster planning, time management, and computerized prescription refills.
    • Consistent, meticulous coverage throughout the main text, IRM, SG, DVDs, Evolve, and more provide reliable content and unparalleled accuracy.
    • Over 90 procedural videos on DVD and online provide a visual representation of important procedures.
    • Expanded Student Evolve site contains all animations, games (such as Quiz Show and Road to Recovery), drag-and-drop exercises, Apply your Knowledge exercises, Prepare for Certification exercises, matching exercises, and other helpful activities such as blood pressure readings, determining height and weight, and drawing up medication.
    • What Would You Do? What Would You Not Do? boxes and responses offer applications of real-life case studies.
    • Clear and concise Anatomy and Physiology coverage covers the basics of A&P and eliminates the need for a separate A&P text.
    • Content updates reflect the latest competencies for medical assistants and ensure you have the most current information on the newest trends and updates in the medical assisting world.
    • 8th grade reading level makes material approachable and easy to understand.
    • New chapter on Emergency Preparedness offers a well-rounded perspective on what to do in specific emergency situations.
    • New OSHA Bloodborne Pathogens video improves your understanding of personal safety following the OSHA standards.
    • Pronunciation section in the Terminology Review gives you confidence with pronunciation and medical knowledge.
    • Application to EMR where appropriate prepares you for the real world by dealing with electronic medical records.
    Print version of the book includes free access to the app (web, iOS, and Android), which offers interactive Q&A review plus the entire text of the print book! Please note the app is included with print purchase only.

    Epilepsy Board Review is designed as a primary study tool to help candidates prepare for the epilepsy board certification exam. Using structured question formats typically encountered on the boards, this book covers the base knowledge tested and allows users to assess their proficiency in a wide range of topics necessary to achieve subspecialty certification in the field of epilepsy.

    This high-yield review contains over 360 questions with answers, detailed explanations, and references. The book consists of four parts that cover the phenomenology of seizures and epileptic disorders, basic EEG, diagnostic evaluation of seizures and epilepsy, and treatment of epilepsy. Liberal use of images illustrating specific EEG and neuroimaging findings enhances interpretive skills and facilitates translation of visual knowledge into the clinical practice of epilepsy. Questions are randomized and include both case-based and stand-alone items to familiarize candidates with the question types and formats typically encountered on an exam.

    Key Features:

    • The first dedicated self-assessment and review book for the epilepsy board certification exam
    • Contains over 360 board-type questions with answers, detailed rationales, and references
    • Facilitates recall of must-know information and helps identify knowledge gaps for further study
    • Includes case-based and stand-alone questions, supplemented by 87 state-of-the-art illustrations, to ensure familiarity with the testing environment encountered in a board exam
    Get everything you need to review for the NCLEX-PN® exam from one trusted source! With over 4,500 high-quality review questions, this unique, bestselling review and preparation guide offers the perfect combination of core content review, comprehensive rationales, and detailed test-taking strategies from the NCLEX expert herself: Linda Silvestri. Updated to reflect the latest NCLEX-PN test plan, this new edition and companion Evolve website help you hone your understanding of all the important NCLEX-PN content areas.
    • Full-color design
    • makes for a more visually engaging learning experience.
    • 12 pharmacology chapters address the emphasis on pharmacology questions on the NCLEX-PN exam.
    • Priority Nursing Actions boxes outline and explain clinical emergent situations requiring immediate action, including detailed rationales and textbook references to help you strengthen prioritizing skills in clinical and testing situations.
    • Pyramid Alert boxes reinforce learning of essential content frequently tested on the NCLEX-PN exam.
    • Reference to a Mosby or Saunders textbook gives you resources for further study and self-remediation.
    • Question codes categorize each question by cognitive level, client needs area, integrated process, clinical content area, and priority concepts to allow you multiple study and exam selections on the companion Evolve site.
    • Inclusion of all alternate item formats (multiple response, ordered response, fill-in-the-blank, figure, chart/exhibit, audio, and video questions) offers practice with mastering prioritizing, decision-making, and critical thinking skills, and help prepare you for this additional component of the new test plan for NCLEX-PN.
    • Pyramid to Success sections supply an overview of the chapter, guidance and direction regarding the focus of review in the content area, and its relative importance to the most recent NCLEX-PN text plan.
    • Pyramid Points identify content that typically appears on the NCLEX-PN exam.
    • Pyramid Terms give you a quick review of each content area.
    • Introductory chapters on preparation guidance for the NCLEX-PN, nonacademic preparation, test-taking strategies, the CAT format, and the NCLEX-PN are presented from a new graduate’s perspective.
    • Companion Evolve site allows for automatic software updates to allow you to check for changes and updates to content or functionality throughout the life of the edition.
    Provides an interdisciplinary approach to the veterinary dental patient and offers guidance on all aspects of integrating dentistry into veterinary general practice

    The Veterinary Dental Patient: A Multidisciplinary Approach helps veterinarians understand the dental aspects of every canine and feline patient and shows them how to effectively manage their oral health. It also provides guidance to the rest of the veterinary team so they can offer a coordinated approach when recommending and performing veterinary dentistry as a regular part of general practice.

    Edited by two prominent veterinary dentists who are Board Certified in both Europe and the United States, the text includes the latest information on safe anesthetic and monitoring protocols, accurate diagnosis and management, and referring patients to specialists. Chapters cover: establishing a dental presence in general veterinary practice; nutrition, oral health, and feeding dental patients; local, regional, and systemic complications of dental diseases; pain management; ophthalmic considerations; common situations for malpractice and mistakes; oral and maxillofacial surgery; extraction techniques and equipment; drug dosages and more. The book also offers several helpful appendixes.

    The Veterinary Dental Patient: A Multidisciplinary Approach is an essential book for all vets in general small animal practice as well as the wider veterinary team, including managers, veterinary nurses and technicians, and administrative staff.

    A consolidated and comprehensive reference on ligand-binding assays

    Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field.

    Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include:

    • A general discussion of challenges and proven approaches in the development of ligand-binding assays

    • More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline

    • A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules

    • A practical approach to "fit-for-purpose" validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies

    Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.

    The most widely used and highly regarded textbook and reference of emergency medicine -- Endorsed by the American College of Emergency Physicians

    The 8th edition of Tintinalli’s Emergency Medicine provides the depth and breadth of coverage that reflects the complexity and expertise needed to practice emergency medicine successfully in today’s fast–paced environments. It is an important contemporary clinical emergency care resource for physicians, NPs, and PAs who practice emergency medicine and for emergency medicine and pediatric emergency medicine fellows. It remains the preferred study guide for in-training and board examinations and recertification.

    NEW to this edition:
    • Full-color design with more tables than ever to succinctly present key information
    • Extensive updates to all sections, incorporating the latest guidelines, evidence-based protocols, and relevant research
    • Expanded pediatric section, with complete clinical information for general and pediatric emergency physicians
    • Expanded coverage of common emergency department procedures, with improved illustrations
    • Online access to more than 30 videos, covering a wide range of procedural and diagnostic topics and focusing on the latest ultrasound-guided techniques

    From the reviews of the seventh edition:
    "Collectively, they have once again produced an excellent text that manages to cover the broad scope of emergency medicine while remaining an easily readable and practical resource....Last, for the inevitable comparison of this current edition of Tintinalli's Emergency Medicine with other available emergency medicine textbooks available: in my opinion, Tintinalli’s still comes out on top. It is more concise and easier to read than some, yet it covers the breadth of emergency medicine practice more comprehensively than others....Just as previous editions did, the seventh presents all of the most pertinent and up-to-date information in a well-organized format that is comprehensive yet easy to read. That and many of the attractive new features in this current edition will ensure its place on my bookshelf for years to come."—JAMA

    The evolving field of emergency medical services (EMS) requires professional educators who are knowledgeable about teaching and learning strategies, classroom management, assessment and evaluation, technology in learning, legal implications in education, program infrastructure design, and administering programs of excellence to meet state and national accreditation guidelines. Foundations of Education: An EMS Approach, Third Edition, provides EMS educators with the tools, ideas, and information necessary to succeed in each of these areas. The content reflects how current educational knowledge and theory uniquely apply to EMS students, educators, and programs. This textbook is used in the NAEMSE Instructor Courses, and is an excellent reference for all EMS educators, as well as educators in allied health professions. Evidence-Based Content In addition to foundational topics such as teaching philosophy and classroom management, the text covers brain-based learning, accreditation and program evaluation, emerging technologies, and assessment strategies. It guides educators to write objectives, prepare lesson plans, and deliver education in engaging ways to maximize student learning. Grounded in this information, EMS educators can promote effective education regardless of the type of course or setting. Highlights -Covers current educational theory and teaching methodologies specific to EMS -Meets and exceeds the latest DOT National Guidelines for Educating EMS Instructors -Offer practical advice and scenarios in the form of Teaching Tips and Case in Points
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