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NIH Intramural Research Program, Our Research Changes Lives

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COVID-19


Get the latest public health information from the CDC at https://www.cdc.gov/coronavirus/2019-ncov/index.html

Get the latest research information from NIH at https://covid19.nih.gov/

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Research in Action: Shining a Light on Emotion


Mario Penzo uses cutting-edge genetic techniques to observe and influence brain circuits involved in stress and anxiety.

Enter the Lab

One Program,
Many People,
Infinite Possibilities


A premier environment where creative scientists conduct fundamental biomedical research for the betterment of human health—we are the IRP.

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Speaking of Science Podcast


Hear conversations with world-leading researchers working at the NIH IRP on challenges across the spectrum of biomedicine.

Listen in

SciBites Video Shorts


Watch IRP researchers provide a quick taste of their scientific projects.

Satisfy Your Appetite

COVID-19


Get the latest public health information from the CDC at https://www.cdc.gov/coronavirus/2019-ncov/index.html

Get the latest research information from NIH at https://covid19.nih.gov/

Learn more

Research in Action: Shining a Light on Emotion


Mario Penzo uses cutting-edge genetic techniques to observe and influence brain circuits involved in stress and anxiety.

Enter the Lab

Welcome to the IRP

The Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH), known for its synergistic approach to biomedical science. We invite you to explore the possibilities.

  • Scientific Focus Areas
  • Principal Investigators
  • Accomplishments
  • Accelerating Science

Research in Action

Learn about our researchers, their goals, achievements, inspirational moments, and most of all, why they are passionate about the research they do here.

A Broken Link in the Chain

Janet Hall explores the cascading effects of hormonal disruptions on the reproductive system.

View story

Cracking the Tubulin Code

Antonina Roll-Mecak examines how tubulin diversity might affect cell shape, movement, and recovery after injury.

View story

Shining a Light on Emotion

Mario Penzo uses cutting-edge genetic techniques to observe and influence brain circuits involved in stress and anxiety.

View story

Virtual Realities, Real Discoveries

Susan Persky uses immersive simulations to understand how genomic information influences people’s health behaviors.

View story

A Feel For Collaboration

Alex Chesler works with colleagues across the IRP to uncover the mysteries of touch and pain.

View story

A Broken Link in the Chain

Janet Hall explores the cascading effects of hormonal disruptions on the reproductive system.

View story

Cracking the Tubulin Code

Antonina Roll-Mecak examines how tubulin diversity might affect cell shape, movement, and recovery after injury.

View story

Shining a Light on Emotion

Mario Penzo uses cutting-edge genetic techniques to observe and influence brain circuits involved in stress and anxiety.

View story

Virtual Realities, Real Discoveries

Susan Persky uses immersive simulations to understand how genomic information influences people’s health behaviors.

View story

View all stories

From Our Blog

A Ray of Hope for a Rare and Deadly Skin Cancer
IRP Research Leads to First FDA-Approved Therapy for Merkel Cell Carcinoma
By Melissa Glim
Tuesday, May 4, 2021

How a Marker for Genetic Damage Changed the Study of DNA
Decades Later, IRP Researcher’s Discovery Is Used in Labs Around the World
By Melissa Glim
Wednesday, April 21, 2021

IRP’s Cynthia Dunbar Elected to National Academy of Medicine
Studies of Blood Stem Cells Stimulate Pioneering Therapeutic Approaches
By Melissa Glim
Wednesday, April 14, 2021

I am Intramural Blog

Our Tweets

Tweets by IRPatNIH

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In the News

May 3
Scientists identify small-molecule cocktail to improve stem cell use in research and disease treatments
Apr 22
International research teams explore genetic effects of Chernobyl radiation
Apr 16
Experimental antiviral for COVID-19 effective in hamster study
Apr 14
Most differences in DNA binding compounds found at birth in children conceived by IVF not seen in early childhood
Apr 13
Drug testing approach uncovers effective combination for treating small cell lung cancer

View all news

Calendar of Events

Tuesday, May 11, 2021, 9:00 am to Wednesday, May 12, 2021, 6:30 pm (registration required)
Vivian Pinn Symposium: Integrating Sex and Gender into Biomedical Research as a Path for Better Science and Innovation

Wednesday, May 12, 2021, 8:00 am to Thursday, May 13, 2021, 5:30 pm (registration required)
NHLBI Systems Biology Symposium

Tuesday, May 18, 2021, 2:00 pm to 3:00 pm
Development of an Instrument to Assess Psychosocial Spiritual Healing: The NIH HEALS

Monday, June 21, 2021, 1:00 pm to 5:00 pm (register by May 15)
NCI-CONNECT Survivorship Care in Neuro-Oncology Symposium

Tuesday, June 29, 2021 to Wednesday, June 30, 2021 (apply by May 10 at 12:00 PM EDT)
Future Research Leaders Conference

View all events

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    • Accelerating Science
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NIH Intramural Research Program, Our Research Changes Lives

  • Search
  • Menu
  • Close
  • Podcast
  • Instagram
  • Twitter
  • YouTube
  • LinkedIn
  • About UsExpand
    • What Is the IRP?
    • History
    • HonorsExpand
      • Nobel Prize
      • Lasker Award
      • Breakthrough Prize
      • Presidential Early Career Award for Scientists and Engineers (PECASE)
      • Presidential Medal of Freedom
      • National Medal of Science
      • Searle Scholars
      • The National Academy of Sciences
      • The National Academy of Medicine
      • The National Academy of Engineering
      • The American Academy of Arts and Sciences
      • National Medal of Technology & Innovation
      • Samuel J. Heyman Service to America Medals
      • Crafoord Prize
      • Canada Gairdner Awards
    • Organization & Leadership
    • Our ProgramsExpand
      • NCI
      • NEI
      • NHGRI
      • NHLBI
      • NIA
      • NIAAA
      • NIAID
      • NIAMS
      • NIBIB
      • NICHD
      • NIDA
      • NIDCD
      • NIDCR
      • NIDDK
      • NIEHS
      • NIMH
      • NIMHD
      • NINDS
      • NINR
      • NLM
      • CC
      • CIT
      • NCATS
      • NCCIH
    • Research Campus Locations
    • Contact Information
  • Our ResearchExpand
    • Scientific Focus AreasExpand
      • Biomedical Engineering & Biophysics
      • Cancer Biology
      • Cell Biology
      • Chemical Biology
      • Chromosome Biology
      • Clinical Research
      • Computational Biology
      • Developmental Biology
      • Epidemiology
      • Genetics & Genomics
      • Health Disparities
      • Immunology
      • Microbiology & Infectious Diseases
      • Molecular Biology & Biochemistry
      • Molecular Pharmacology
      • Neuroscience
      • RNA Biology
      • Social & Behavioral Sciences
      • Stem Cell Biology
      • Structural Biology
      • Systems Biology
      • Virology
    • Principal InvestigatorsExpand
      • View by Investigator Name
      • View by Scientific Focus Area
    • AccomplishmentsExpand
      • View All Accomplishments by Date
      • View All Health Topics
      • The Body
      • Health & Wellness
      • Conditions & Diseases
      • Procedures
    • Accelerating ScienceExpand
      • Investing in Cutting-Edge Animal Models
      • Creating Cell-Based Therapies
      • Advancing Computational and Structural Biology
      • Combating Drug Resistance
      • Developing Novel Imaging Techniques
      • Charting the Pathways of Inflammation
      • Zooming in on the Microbiome
      • Uncovering New Opportunities for Natural Products
      • Stimulating Neuroscience Research
      • Pursuing Precision Medicine
      • Unlocking the Potential of RNA Biology and Therapeutics
      • Producing Novel Vaccines
    • Research in ActionExpand
      • View All Stories
      • Shining a Light on Emotion
      • Virtual Realities, Real Discoveries
      • A Feel For Collaboration
      • A Broken Link in the Chain
    • Research ResourcesExpand
      • Supercomputing
    • IRP Review Process
    • Commercializing Inventions
  • NIH Clinical CenterExpand
    • Clinical Center Facilities
    • Advancing Translational Science
    • Clinical TrialsExpand
      • Get Involved with Clinical Research
      • Physician Resources
  • News & EventsExpand
    • In the News
    • I am Intramural Blog
    • Speaking of Science Podcast
    • SciBites Video Shorts
    • The NIH Catalyst Newsletter
    • Events
  • CareersExpand
    • Faculty-Level Scientific CareersExpand
      • Chief Medical Officer, CC
      • Chief, Neurotology Branch, NIDCD
      • Clinical Director, NINR
      • Scientific Director, NHGRI
      • Scientific Director, NICHD
      • Scientific Director, NIDCD
      • Tenure-Eligible Senior Investigator, NCI
      • Tenure-track or Tenure-eligible Investigator, NLM
    • Trans-NIH Scientific RecruitmentsExpand
      • Stadtman Tenure-Track InvestigatorsExpand
        • Application Details
        • Science, the Stadtman Way
      • Lasker Clinical Research ScholarsExpand
        • Nurturing the Next Generation of Clinical Researchers
      • Early Independent ScientistsExpand
        • Application Details
    • Scientific & Clinical Careers
    • Administrative Careers
  • Research TrainingExpand
    • Program Information
    • Training Opportunities
    • NIH Work/Life Resources